Almonds and Olivez

Health and Overall Wellness

SHOP
Health Benefits of Turmeric

Turmeric – An Aged old Spice – Five (5) Awesome ‘must know’ Health Benefits.

TABLE OF CONTENTS

Turmeric or Curcuma Longa L, is an aged old spice that has been used both as a seasoning and imparting distinctive flavours to food worldwide, particularly in Asian cuisine, where it is treasured both as a spice as well as part of traditional medicine for the treatments of wounds, inflammation, pain, digestive disorders among others due to its potent anti-inflammatory and antioxidants properties.   

However, most of us are familiar with one of its infamous bi-product – Curry Powder which is usually a combination of spices and herbs such as pepper, cumin, coriander, ginger and of course, turmeric.  Nonetheless, while the seasonings in curry may differ as per country or region, the one ingredient that remains constant is ‘turmeric.’

Research has shown that turmeric along with its bio-active curcuminoid polyphenols could benefit many chronic conditions such as arthritis and diabetes. To this extent, this infamous spice is said to be widely used in the Middle East and Asia as well as in many Western households due to its purported benefits to human health. 

For example, in India, turmeric is often used in curry dishes while in Japan it is widely used for teas and served in drinks in Korea.  It is also used in mustard sauces, cheese, butter and chips in the United States.  However, in countries like Thailand, China and Malaysia it is often used in cosmetics, as a colourant and as an antiseptic respectively (Gupta et al. 2013).  Curcumin, a major compound of the turmeric root, is usually used in capsules, tablets, ointments, energy drinks as well as in soaps (Gupta et al. 2013) 

However, research has shown that raw turmeric is constrained due to its poor bioavailability when it comes to human consumption.  Nonetheless, over the years, many clinical studies have advanced scientists’ understanding of this famed spice, especially as it relates to ways in which it can be formulated to become more absorbable and thus beneficial to human health.  Let’s discuss!

The Discussion

Turmeric is a botanical spice that belongs to the Zingiberaceae family which includes the likes of ginger, cardamom and arrowroot. It is widely used in Asian countries due to its antioxidant, anti-inflammatory (Lestari et al. 2014), antimutagenic, antimicrobial (Mahady et al. 2002; Reddy et al. 2005) and anticancer properties (Vera-Ramirez et al. 2013; Wright et al. 2013).

It has three (3) main curcuminoids namely – curcumin, demethoxycurcumin, and bisdemethoxycurcumin, all these three compounds are collectively known as curcuminoids.   Of the three (3), curcumin, which is also called diferuloylmethane is the main natural polyphenol that is found in the rhizome of Curcuma Longa (turmeric) as well as in other Curcuma species (Aggarwal et al. 2003).  It is also the most popular and the most researched due to its levels of bioavailability to humans.  

Curcumin or diferuloylmethane is a substance that gives curry its ‘yellow’ pigment. Diferuloylmethane makes up sixty (60) to seventy (70) percent of crude turmeric extract and is the main curcuminoid that is investigated due to its health-promoting activities (Nelson et al, 2017).  In addition to its potent curcumin contents, turmeric also contains sugars, proteins, resins and volatile oils such as turmerone, atlantone and zingiberene, some of which may be bioavailable to humans (Nelson et al, 2017; Eke-Okoro et al. 2018; et al).

Several pre-clinical investigations have identified many potential health benefits of turmeric.  Some of the purported benefits of turmeric include helping with heart health, arthritis pain, Alzheimer’s disease, digestive disorders and metabolic syndrome (MetS) (Singletary, 2015).   The report indicates that before 2019, over One Hundred and Fifty (150) pre-clinical and clinical reports have been published on the impact of turmeric on both the prevention and treatment of arthritis and type 2 diabetes (Metabolic Syndrome). (Singletary, 2015). 

It is also said to help in the management of inflammatory and degenerative eye conditions [Mazzolani and Togni, 2013; Allegri et al. 2010).  Turmeric has also been shown to benefit the kidneys (Trujillo et al. 2013).

Despite its purported health benefits, many studies have shown that the small amounts of curcuminoids in turmeric powder are very poorly absorbed by humans.  In fact, research shows that curcuminoids from raw turmeric have an exceptionally low absorbable rate which is considered to be about 3% (Qin et al. 2017; Sahebkar, 2014).

Further, the culinary proportion that is added to foods is stated to be unlikely to provide any meaningful health benefits, especially for conditions such as arthritis and inflammation, which are some of the conditions mostly studied.

Nonetheless, over the years, considerable research through clinical trials has been exploring many mechanisms that could assist with the delivery of both turmeric and curcuminoids.  Some of the methods of delivery tested or observed include adding the compound piperine. Piperine is a phytochemical that can enhance intestinal uptake of curcumin among other novel delivery systems (Sanidad et al. 2019; Prasad et al. 2014; et al.). 

Piperine is a major active component of black pepper and is said to be able to enhance the bioavailability of turmeric by up to Two Thousand percent (2000%) (Shoba et al. 1998).  As such, turmeric’s poor bioavailability could simply be resolved by adding a little black pepper before consuming the powder or the raw root as well as by ensuring that black pepper or some other methods of bioavailability are included in your turmeric-related products.

Another method of delivery that has been researched is that of having curcuminoids encapsulated with the essential oils of turmeric, particularly the oil – turmerone which could enhance intestinal permeability.   Researchers have observed that both methods, the addition of piperine or turmeric essential oils have shown remarkable improvements in oral bioavailability in humans (Singletary, 2015).

In this article, we will be exploring Five (5) health benefits of turmeric namely, its effects on arthritis pain, diabetes and oxidative stress, its cardiovascular health benefits, nerve and cognitive function properties and its effects on the management and treatment of infections and parasitic diseases.  

You can learn more about how you can add turmeric to your morning routine via this video:

Is there a difference between Turmeric and Curcumin?

Yes! Notably, when it comes to health, turmeric and curcumin are not considered the same even though they are sometimes used interchangeably.  Curcumin comes from turmeric.  It is the main natural polyphenol that is found in the rhizome of the turmeric plant as well as other Curcuma species.  It is this extracted compound that gives turmeric root that bright yellow colour as well as what is present in ‘curry powder.’  

As such, curcumin is usually a compound that is found in many supplements (capsules or tablets) or turmeric-related products such as drinks, cosmetics, ointments etc.

Due to its interchangeable use, there is a constant debate as to which is more beneficial to the body, the whole food (root), powdered versions or its extract – curcumin.  Well, the research varies, as some researchers believe that whole food – turmeric is more beneficial as foods eaten in their whole state often have other nutrients that tend to bolster its benefits.  On the other hand, some researchers argue that the extract or isolated compound – curcumin, is more beneficial as it may have more potent antioxidant activity. 

Nonetheless, I have not seen one definitive answer as to which may be better.  Importantly though, one must ensure that whichever form is available to them is ‘absorbable’ by the body. As this is the only way you will reap the nutrients. You can read more about its methods of absorbability throughout the article.

Five (5) Awesome ‘must know’ Health Benefits of Turmeric:
  • Alleviation of Arthritis Pain.
  • Management of Diabetes and Oxidative Stress.
  • Cardiovascular Health.
  • Nerves and Cognitive Function.
  • Management and treatment of Infections and Parasitic Conditions.
Turmeric and Arthritis

According to research, arthritis is a chronic condition that is said to affect over Two Hundred and Fifty (250) million people worldwide (Hunter et al. 2014; Vos et al. 2013).   Arthritis affects the joints of the body which then become stiff and painful due to inflammation.  While several pharmaceutical options exist for the treatment of this condition, researchers have been experimenting with natural ways in which to manage it. 

Additionally, over Twenty-one (21) clinical trials have been conducted to investigate the impact of turmeric powder or curcuminoid-containing supplements on both the signs and symptoms of arthritis (Singletary, 2015).

The majority of the clinical trials looked at arthritis, especially knee osteoarthritis.  Further, many of the patients who participated were female, at least Seventy-five (75) percent and were from countries in the Middle East and Asia.  The trial investigated the intensity of the pain as well as the improvements in the patient’s physical functioning. 

The curcuminoids used were administered orally in different dosage formulations (Deodhar et al, 1980; Pinsornsak and Niempoog, 2012; Kuptinratsaikul et al. 2014; Srivastava et al. 2016).  The curcuminoid formation was primarily turmeric powder or dried organic solvent which was extracted from the powder and which may have contained the volatile oil portion.

The doses administered in most of these studies were 90 mg/day to 1.2 g/day for a two (2) week period.  The results showed that the participants experienced significant improvement in arthritic symptoms such as stiffness and walking pain (Deodhar et al. 1980; Kuptniratsaikul et al. 2014).  All the studies showed some improvement in the arthritis symptoms of the patients. 

Further, according to research, systematic reviews and meta-analyses of particular arthritis trials provided evidence that supported the efficacy of curcuminoids in the treatment of arthritis with far fewer adverse effects than with non-steroidal anti-inflammatory drugs (NSAIDs) (Rahimnia et al. 2015; Haroyan et al. 2018; Gaffey et al. 2017; WuJ et al. 2019; et al.).

Nonetheless, due to several limitations, some of the clinical trials have not been implemented.  One thing that was clear though, was that curcumin could improve the quality of life of arthritis patients if it is used in absorbable formats (Singletary, 2015).   Therefore, more research is certainly warranted.

Turmeric and Diabetes and Oxidative Stress

Several experimental studies on mice suggest that curcumin administered at 80 mg/kg, for say 21 days can alleviate some of the risk factors for diabetes as it can reduce blood sugar (hyperglycemia) – (Pari et al. 2008; Aggarwal and Harikumar, 2009).  In addition, to a reduction in blood glucose levels, studies have shown that curcumin has the potential to increase plasma insulin levels, prevent diabetic cataracts and renal dysfunction as well as relieve neuropathic pain associated with diabetes (Pari et al. 2008; Chiu et al. 2009).

Further, an alcohol extract of turmeric (1.5g/day) given to pre-diabetic individuals for nine (9) months showed a significant reduction in fasting glucose, haemoglobin and insulin resistance compared with controls (Chuengsamarn, 2012).  The study also showed that the alcohol extract reduced the prevalence of newly diagnosed type 2 diabetes mellitus. 

As such, the researchers concluded the importance of long-term use in the examination of the photo-chemicals of turmeric, especially in the early stages of the progression of diabetes.  Additionally, a study by (Tariq et al. 2016) also observed improvement in blood lipid profile when turmeric was consumed in a tea format. 

Nonetheless, limited evidence has been found in human studies on the efficacy of curcumin.  However, in a study from way back in 1972, it was found that curcumin had the potential to alter blood glucose levels in persons suffering from diabetes (Srinivasan, 1972).  In addition, a more recent study by (Ushatani et al. 2008) using a formulation of curcuminoids showed a positive effect on blood levels of inflammatory stress biomarkers in individuals with type 2 diabetes.

Turmeric and Cardiovascular Health

Studies have shown that curcumin has displayed many cardio-protective properties.  This is due in large to its anti-inflammatory properties which are slated and could potentially protect against cardiac injuries as per several animal studies.  According to these studies, curcumin administered intravenously between 70 to 100 umol/kg was observed to protect the heart against damage after cardiac ischemia and reperfusion (Aggarwal et al. 2009, Srivastava and Mehta, 2009; Ali et al. 2009).

Further, a meta-analysis of seven (7) trials with One Hundred and Thirty (130) patients that exhibited baseline risk factors of cardiovascular disease, showed that turmeric and curcuminoids significantly reduce both low-density lipoprotein (LDL) and triglycerides levels in the blood.  However, it was not observed to improve high-density lipoprotein (HDL) or total cholesterol levels.  On the other hand, in a study by Sahebkar (2014), it was found that there were no significant effects of curcuminoids on blood lipid parameters. 

While several factors could have contributed to the inconsistencies in some of the findings, research suggests that turmeric formulation, dosage, one’s diet, lifestyle and health will dictate the impact of turmeric on one’s overall health.  Research also suggests that the impact, significant or otherwise will be dependent on the duration of usage.  Research has shown that long-term usage may produce the best results especially when it comes to certain conditions as seen above in the Nine (9)- month study by Chuengsamarn, (2012).

Turmeric and Nerve and Cognitive Function

Studies have shown that curcumin may be able to lessen the development as well as the progression of Alzheimer’s disease.  This was observed in an in vitro study which showed that the anti-inflammatory properties of curcumin exhibited signs of being able to counteract the degeneration of nerve cells (Aggarwal and Harikumar, 2009; Strimpakos and Sharma, 2008; Ringman et al. 2005; et al.).

Further, in an animal study, it was found that curcumin administered at dosages of 160-5000 ppm was able to suppress the build-up of plaque and other neurodegenerative conditions (Aggarwal and Harikumar, 2009; Strimpakos and Sharma, 2008; Ringman et al. 2005).  In addition, several animal studies have shown that curcumin was able to improve memory function and cognition (Ringman et al. 2005; Ahmed and Gilani, 2009; et al.) as well as improve symptoms of dementia (Ringman et al. 2005). 

It was also noted to be able to effectively counteract oxidative stress as well as impaired cognition caused by traumatic brain injury (Wu et al, 2006, Sharma et al. 2009).

Turmeric and Infections and Parasitic Conditions

Research has been mixed as it relates to curcumin’s effects in inhibiting microbial and viral infections.  This was because some research showed it was ineffective in reducing viral loads in individuals with the human immunodeficiency virus (HIV) even though it was purportedly able to reduce diarrhea caused by HIV (Hsu & Cheng, 2007; Conteas et al. 2009). 

However, a study by Agarwal et al. (2008) showed curcumin antibacterial activity in a human clinical study of helicobacter pylori as well as its potential to significantly reduce gastric damage caused by the pylori bacterium.

In another study conducted with mice administered with curcumin at 400 mg/kg per day, it was found that curcumin was able to decrease the parasitic burden in the body as well as liver pathology (Allam, 2009).  Further, preliminary findings also suggest that curcumin may be beneficial in the prevention and treatment of conditions such as psoriasis Hsu & Cheng, (2007) as well as could be used as a non-toxic agent in the treatment of many types of other skin disorders (Aggarwal et al. 2009; Kurd et al. 2008).

Safety and Side Effects of Turmeric

Turmeric or its essential oils are considered generally safe by the Food and Drug Administration (FDA). However, as per curcuminoids containing products or supplements, no safety limits or precautions have been published by the FDA.   As such, it is simply approved by the FDA as ‘Generally Recognized As Safe (GRAS) [Gupta et al. 2013] and thus, is said to have a good tolerability profile even at doses up to 8000 mg/day (Basnet & Skalko-Basnet, 2011).  

Further, animal studies have shown the relatively low toxicity potential of curcuminoids up to 12g/day (Anand et al. 2007; Aggarwal et al. 2007).  As such, generally, human intake of up to 8g/day has been touted as tolerable with only minor negative effects such as gastrointestinal distress.

Nonetheless, studies have shown that there are some negative effects of consuming turmeric.  This was reported in a study conducted by (Lao et al. 2006) with Seven (7) individuals receiving 500-1200 mg per day. Within Seventy-two (72) hours of consuming the curcumin, the participants reportedly experienced diarrhea, headache, rash and yellow stool. 

Negative effects were also reported by participants in another study conducted by (Sharma et al. 2004).  In this study, the participants received 0.45 to 3.6 grams of curcumin per day for a duration of One (1) to four (4) months.  The participants reported side effects of nausea, diarrhea as well as an increase in serum alkaline phosphatase and lactate dehydrogenase contents.

Alkaline phosphatase is a type of enzyme that is found in the body.  Enzymes, in general, are proteins which help with the body’s chemical reactions. Lactate dehydrogenase is also a special type of enzyme that is found in almost all cells of the body and helps the body to produce energy among other critical functions.

There is also the possibility of a drug interaction following curcuminoid intake as it can both inhibit as well as enhance the effects of particular drugs in humans as reported by (Eke-Okoro et al. 2018; Jurenka, 2009). As such, as with any herbal supplement, one must seek medical advice before consumption, especially if on medications.

Illustrative Summary

Here is a summary of the Five(5)  ‘must know’ health benefits of TURMERIC.

Tumeric Health Benefits

Let’s Sum Up!

The use of turmeric has become extensively popular due to its many purported potential health benefits which include its effects on cardiovascular health, diabetes, arthritis pain, and cognitive function as well as the treatment of infections and parasitic conditions, including psoriasis.

Nonetheless, while it is largely touted for its anti-inflammatory properties, research contends that most of the benefits of turmeric may not be experienced due to its low absorption rate by humans. 

However, researchers have found ways in which this potent spice can become absorbable by the human body.  One such means is the addition of the substance – piperine.  Piperine is an active compound that is found in black pepper.  According to research, adding black pepper to your turmeric dishes can enhance its bioavailability by up to Two Thousand (2000) percent.

While turmeric is largely considered safe, research has shown that intake of up to 1200 mg/day or in some cases even lower can cause digestive discomfort, diarrhea and even headaches.  Turmeric may also potentially inhibit as well as enhance the effectiveness of certain medications.  As such, it is always best to consult your healthcare professional before consuming turmeric or its related compounds.

Nonetheless, this little ginger-like spice can be a beneficial addition to one’s diet due to its myriad of potential health benefits, especially for those on a health and wellness journey.  Turmeric can also be added to one’s diet via many different means including curry dishes, tea, rice and milk among others, the possibilities are endless.

You can find a few of these recipes below to get you on your way.  You can also check out our Recipe EBook which contains some of our most popular recipes from the blog, including a turmeric dish.

You can also see how you can implement turmeric in the long term in this video:

References

  • Aggarwal, B.B.; Kumar, A.; Bharti, A.C. Anticancer potential of curcumin: Preclinical and clinical studies.
  • Anticancer Res. 2003, 23, 363–398.
  • Aggarwal B, Surh Y, Sishodia S. Clinical studies with curcumin. Adv Exp Med Biol. 2007;595:471Y480.
  • Agarwal D, Saikla D, Tiwari R, et al. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents.
  • Plant Med. 2008;74:1828Y1831.
  • Aggarwal B, Harikumar K. Potential therapeutic effects of curcumin, the anti-inflammatory agent in turmeric, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J
  • Biochem Cell Biol. 2009;41:40Y59.
  • Ahmed T, Gilani A. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer’s disease. Pharmacol Biochem Behav. 2009;91:554Y559.
  • Allam G. Immunomodulatory effects of curcumin treatment on murine schistosomiasis treatment. Immunobiology. 2009;214:712Y727.
  • Ali M, Maidagal M, Goli D. Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally-induced myocardial infarction in rats. Pharmazie. 2009;64:132Y136.
  • Allegri, P.; Mastromarino, A.; Neri, P. Management of chronic anterior uveitis relapses: Efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin. Ophthalmol. 2010, 4, 1201–1206.
  • Anand P, Kunnumakkara A, Newman R, Aggarwal B. Bioavailability of curcumin: problems and promises. Mol
  • Pharm. 2007;4:807Y818.
  • Basnet, P.; Skalko-Basnet, N. Curcumin: An anti-inflammatory molecule from a curry spice on the path to
  • cancer treatment. Molecules 2011, 16, 4567–4598.
  • Chiu J, Khan Z, Farhangkhoee H, Chakrabati S. Curcumin prevents diabetes-associated abnormalities in the kidneys
  • by inhibiting p300 and nuclear factor-kappaB. Nutrition. 2009;25:964Y972.
  • Chuengsamarn S, Rattanamongkolgul S, Luchapudiporn R, et al. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35:2121–2127.
  • Conteas C, Panossian A, Tran T, Singh H. Treatment of HIV-associated diarrhea with curcumin. Dig Dis Sci.
  • 2009;54:2188Y2191.
  • Deodhar S, Sethi R, Srimal R. Preliminary study on anti-rheumatic activity of curcumin (diferuloyl methane). Ind J Med Res. 1980;71: 632–634.
  • Eke-Okoro U, Raffa R, Pergolizzi J, et al. Curcumin in turmeric: basic and clinical evidence for a potential role in analgesia. J Clin Pharm Ther. 2018;43:460–466.
  • Gaffey A, Slater H, Porritt K, Campbell J. The effects of curcuminoids on musculoskeletal pain: a systematic review. JBI Database System Rev Implement Rep. 2017;15:486–516.
  • Gupta, S.C.; Patchva, S.; Aggarwal, B.B. Therapeutic Roles of Curcumin: Lessons Learned from Clinical
  • Trials. AAPS J. 2013, 15, 195–218.
  • Haroyan A, Mukuchyan V, Mkrtchyan N, et al. Efficacy and safety of curcumin and its combinationwith boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebocontrolled study. BMC Complement Altern Med. 2018;18:7–22.
  • Hsu C, Cheng A. Clinical studies with curcumin. Adv Exp Med Biol. 2007;595:471Y480.
  • Hunter, D.J.; Schofield, D.; Callander, E. The individual and socioeconomic impact of osteoarthritis.
  • Lancet Nat. Rev. Rheumatol. 2014, 10, 437–441.
  • Jurenka J. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14:141–153.
  • Kuptniratsaikul V, Dajpratham P, TaechaarpornkulW, et al. Efficacy and safety of Curcuma domestica extracts compared to ibuprofen in patients with knee osteoarthritis: amulticenter study. Clin Invest Aging. 2014;9:451–458.
  • Kurd S, Smith N, VanVorhees A, et al. Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: a
  • prospective clinical trial. J Am Dermatol. 2008;58: 625Y631.
  • Lao, C.D.; Ruffin, M.T.; Normolle, D.; Heath, D.D.; Murray, S.I.; Bailey, J.M.; Boggs, M.E.; Crowell, J.; Rock, C.L.; Brenner, D.E. Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med. 2006, 6, 10.
  • Lestari, M.L.; Indrayanto, G. Curcumin. Profiles Drug Subst. Excip. Relat. Methodol. 2014, 39, 113–204.
  • [PubMed]
  • Mahady, G.B.; Pendland, S.L.; Yun, G.; Lu, Z.Z. Turmeric (Curcuma longa) and curcumin inhibit the growth of
  • Helicobacter pylori, a group 1 carcinogen. Anticancer Res. 2002, 22, 4179–4181. [PubMed]
  • Mazzolani, F.; Togni, S. Oral administration of a curcumin-phospholipid delivery system for the treatment of
  • central serous chorioretinopathy: A 12-month follow-up study. Clin. Ophthalmol. 2013, 7, 939–945. [CrossRef]
  • [PubMed]
  • Nelson K, Dahlin J, Bisson J, et al. The essentialmedicinal chemistry of curcumin. J Med Chem. 2017;60:1620–1637.
  • Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008;114:127Y149.
  • Pinsornsak P, Niempoog S. The efficacy of Curcuma longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control study. J Med Assoc Thai. 2012;95(suppl 1): S51–S58.
  • Prasad S, Tyagi A, Aggarwal B. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat. 2014;46: 2–18.
  • Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J. 2017;16:68. doi:10.1186/s12937-017-0293-y.
  • Rahimnia A, Panahi Y, Alishiri G, et al. Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: findings from a randomized doubleblind placebo-controlled trial. Drug Res (Stuttg). 2015;65:521–525.
  • Reddy, R.C.; Vatsala, P.G.; Keshamouni, V.G.; Padmanaban, G.; Rangarajan, P.N. Curcumin for malaria
  • therapy. Biochem. Biophys. Res. Commun. 2005, 326, 472–474
  • Ringman J, Frautschy S, Cole G, Masterman D, Cummings J. A potential role of the curry spice curcumin
  • in Alzheimer’s disease. Curr Alzheimers Res. 2005;2: 131Y136.
  • Sahebkar A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clin Nutr. 2014;33:406–414.
  • Sanidad K, Sukamtoh E, Xiao H, McClements DJ, Zhang G. Curcumin: recent advances in the development of strategies to improve oral bioavailability. Ann Rev Food Sci Technol. 2019; 10:597–617.
  • Sharma, R.A.; Euden, S.A.; Platton, S.L.; Cooke, D.N.; Shafayat, A.; Hewitt, H.R.; Marczylo, T.H.; Morgan, B.;
  • Hemingway, D.; Plummer, S.M. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin. Cancer Res. 2004, 10, 6847–6854.
  • Sharma S, Zhuang Y, Ying Z, Gomez-Pinilla F. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience. 2009;161:1037Y1044
  • Shoba, G.; Joy, D.; Joseph, T.; Majeed, M.; Rajendran, R.; Srinivas, P.S. Influence of piperine on the
  • pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998, 64, 353–356. 
  • Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci. 1972;26:269Y270.
  • Srivastava G, Mehta J. Currying the heart: curcumin and cardioprotection. J Cardiovascul Pharmacol Ther. 2009;
  • 14:22Y27.
  • Srivastava S, SaksenaAK, Khattri S,Kumar S, Dagur RS. Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology. 2016; 24:377–388.
  • Strimpakos A, Sharma R. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal. 2008;10:511Y545.
  • Tariq S, Imran M, Mushtaq Z, Asghar N. Phytopreventive anticholesterolemic and antilipidemic perspectives of zedoary (Curcuma zedoaria roscoe.) herbal tea. Lipids Health Dis. 2016;15:39–48.
  • Trujillo, J.; Chirino, Y.I.; Molina-Jijón, E.; Andérica-Romero, A.C.; Tapia, E.; Pedraza-Chaverrí, J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013, 1, 448–456.
  • Ushatani P, Mateen A, Naidu M, Raju Y, Chandon N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs Res Design. 2008;9:243Y250.
  • Vera-Ramirez, L.; Perez-Lopez, P.; Varela-Lopez, A.; Ramirez-Tortosa, M.; Battino, M.; Quiles, J.L. Curcumin
  • and liver disease. Biofactors 2013, 39, 88–100.
  • Vos, T.; Barber, R.M.; Bell, B.; Bertozzi-Villa, A.; Biryukov, S.; Bolliger, I.; Charlson, F.; Davis, A.; Degenhardt, L.; Dicker, D.; et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study. Lancet 2013, 386, 743–800.
  • Wright, L.E.; Frye, J.B.; Gorti, B.; Timmermann, B.N.; Funk, J.L. Bioactivity of turmeric-derived curcuminoids
  • and related metabolites in breast cancer. Curr. Pharm. Des. 2013, 19, 6218–6225.
  • Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress synaptic plasticity and cognition. Exp Neurol. 2006;197:309Y317.
  • Wu J, Lu M, Zhou Y. Efficacy and side effect of curcumin for the treatment of osteoarthritis: a meta-analysis of randomized control trials. Pak J Pharm Sci. 2019;32:43–51.
Category: Tag: , , , , ,

You cannot copy content of this page