Arthritis is a group of conditions that cause chronic inflammation and damage to the joints, particularly in areas such as the hips and knees. While it was once primarily associated with aging, arthritis can now affect individuals across all age groups, including children in cases such as juvenile arthritis. However, the risk still increases with age, with osteoarthritis being the most common form and rheumatoid arthritis among the more severe types.

Common symptoms include joint pain, inflammation, stiffness, reduced range of motion, and, in advanced cases, deformity. Although there is no definitive cure for arthritis, ongoing research continues to explore new and complementary approaches to managing the condition.

One area of growing interest is the use of plant-based compounds with anti-inflammatory and antioxidant properties. Among these is pine bark extract, commonly known as Pycnogenol, derived from the French maritime pine (Pinus pinaster). But can this natural extract truly support arthritis management, or is the evidence still emerging? Let’s explore what the research says.

Pine bark extract is derived from the bark of the Landes or French maritime pine tree (Pinus maritime).  This particular tree is a member of the Pinaceae family, which includes other well-known species such as cedars (Cedrus), pine (Pinus) and spruce (Picea), etc. (Britannica.com).  The bark extract is famed for its antioxidant properties, which are touted to be effective for healing as well as treating and preventing particular conditions.  However, can it help with arthritis? Let’s discuss!

What is Pine Bark Extract?

Pine bark extract is derived from the bark of the Landes or French maritime pine tree (Pinus maritime).  This particular tree is a member of the Pinaceae family, which includes other well-known species such as cedars (Cedrus), pine (Pinus) and spruce (Picea), etc. (Britannica.com).  The bark extract is famed for its antioxidant properties, which are touted to be effective for healing as well as treating and preventing particular conditions

Its extract is commonly used as a supplement that is used worldwide for its many purported benefits. Usually, you will find the extract under the name pycnogenol, which is the patent under which it is sold.  Pycnogenol is the standardized extract from the bark, and the marketed name of the supplement.  These compounds have a high concentration of polyphenols, which include catechins and phenol acids (Iravani and Zolfaghari, 2011; Blazso et. al., 1994; Rohdewald, 2002).  The polyphenols in this bark are said to make up about 60-75% of its nutritional properties (Rohdewald, 2002).  These potent compounds have been widely studied due to their anti-inflammatory and high-antioxidant activities (Iravani and Zolfaghari, 2011).

Several studies have outlined the purported benefits of these compounds; For example, catechins, which are also plentiful in green tea, are touted to help manage body fat as well as reduce low-density lipoproteins (LDL) cholesterol. Catechin may also be able to prevent as well as manage some other lifestyle diseases (Nagao et. al. 2005).  Pine bark is also known for its flavonols and bioflavonoids, properties that are usually found in fruits and vegetables, particularly leafy greens.

The benefits of its flavonols and bioflavonoid properties were foretold in a story that dates back to a Four Hundred and Fifty (450) years old story of an event that took place in 1534. The story highlighted what happened when a ship carrying the French explorer, Jacques Carter and his crew became stranded at sea. The men then became ill with Scurvy, a disease that is caused by a severe deficiency of vitamin C. Scurvy can become fatal if not treated. 

The crew was instructed to brew a concoction of the pine bark and its needles by Quebec Indians, as the ship was docked in Quebec, Canada.  The brew worked. Many years later, research contends that the flavonols in the bark acted like antioxidants and increased the effectiveness of vitamin C, which is prominently found in the needles of the pine tree (Encyclopedia.com).

For this reason, the antioxidants in pine bark have been grouped as oligomeric proanthocyanidins or OPCs. These antioxidants are said to be able to reduce cholesterol and thus incidences of heart disease, as well as strengthen the body’s collagen production abilities. They are also said to be able to reduce plaque buildup, which can damage the arteries in the long term. As such, pycnogenol is usually used to treat cholesterol issues, circulation, edema and varicose veins.  It is also used to manage symptoms of premenstrual syndrome (PMS), menopause, arthritis and general inflammation in the body (Encyclopedia.com).

In this article, we will be looking at the research surrounding its benefits for arthritic conditions, particularly Osteoarthritis and Rheumatoid arthritis. Rheumatoid arthritis has been reported as one of the most severe types of the condition (Silman and Hochberg, 1994), while osteoarthritis is the most common type of arthritis. 

You may also be interested in our article on pycnogenol and diabetes. You can also read more about arthritis, as well as foods that may help with its management, in this arthritis EBook:  

• EBook – My Little Fingers (A Book on Arthritis) – Science Simplified + Natural ways to manage it!

Pine Bark Extract and Rheumatoid Arthritis

Rheumatoid arthritis is a condition that is said to be caused by both systemic and local inflammation in the body, particularly in areas like the joints of the knees, hence its distinction as an inflammatory disease (Firestein, 2001). The disease is said to affect about one (1%) percent of the adult population, globally (Firestein, 2001).  According to Firestein (2001), Rheumatoid arthritis is an inflammatory disease that can destroy the cartilage of the bones. 

As such, this condition is a painful one and will thus cause sufferers to always seek ways to manage it, seeing that research has contended that there is no known cure.  A few drugs are usually prescribed to manage the pain associated with the condition, such as disease-modifying anti-rheumatoid drugs (DMARDs) and non-steroidal anti-inflammatory drugs (NSAIDs).  DMARDs are usually provided to patients to manage their debilitating effects on the immune system (Shiokawa et. al. 1984; Yasuda et. al. 1994), while NSAIDs are usually used to provide both therapeutic effects and pain relief (Schuna and Megeff, 2000).  

However, with all drugs, there are associated unwanted side effects such as gastric toxicity, among others, while not showing any positive effects on the lesions of the joints for more sustained effects (Santana-Sabagun and Weisman, 2001).  To this extent, researchers have been exploring other means to help sufferers from the condition manage it better. One such is Pine bark extract or ‘pycnogenol’ as it is widely known.

One of the revered compounds of pine bark is Flavangenol (FG).  Flavangenol (FG) is an extract of pine bark, which mostly comprises powerful water-soluble polyphenols such as oligomeric and proanthocyanidins (OPCs) (Ikeguchi et al., 2006).  Flavangenol (FG) is also one of the registered trademarks of a pine bark marketed product. These polyphenols, which are high in antioxidants, include catechins and epicatechin (Ikeguchi et al., 2006) and can be found in foods such as grapes, cranberries, apples, green tea (most teas in general), as well as in pears and red wine (Hellstrom and Mattila, 2008). 

Research has shown that the antioxidants found in the polyphenols were able to either prevent or reduce atherosclerosis (Sato et. al. 2009).  It was also found to positively impact diabetes (Kamuren et. al. 2006;  Maritim et. al. 2003) as well as hypertension (Liu X, et. al. 2004).

The effects of FG on rheumatoid arthritis were observed in a Four (4) week study with collagen-induced arthritis rats. Flavamgenol was used with the infamous pain medication, ibuprofen.  The FG used contained 72.5% polyphenols, with 2.98% catechins.  The rats were placed in three (3) groups: a control group (0.3%) FG, a 1% FG group and a 0.05% Ibuprofen group (Tsubata et. al. 2011).  Each of the groups had a total of eight (8) rats. There was also a non-induced group or a normal group.  This group was fed a standard diet, while the control groups were fed an FG standardized diet or an ibuprofen-containing standard diet. 

The results showed that FG suppressed the progression of collagen-induced arthritis in rats by preventing acute and chronic inflammatory lesions.  However, this was only observed in the rats that were fed the one (1%) percent FG diet and not those of the 0.3% FG diet.  Additionally, the result showed that the 0.05% ibuprofen-containing diet rats suppressed cartilage degeneration and periostitis.

While the researchers contended that the degree of impact between the two experiments will be dependent on the degree of cartilage damage to the knees, FG can still be viewed as a safe and novel substance for the treatment and management of rheumatoid arthritis in humans, not negating further research.

Pine Bark Extract and Osteoarthritis

Osteoarthritis is also an arthritic condition like rheumatoid arthritis. However, this is said to affect mostly the joints of the knees and hips.  While these arthritic conditions can affect persons of any age, osteoarthritis is said to be a disease that predominantly affects the elderly, as it progresses with age (Rohdewald, 2018). 

Some of the symptoms that are associated with this disease include pain and reduced mobility of the joints (Rohdewald, 2018).  These symptoms are usually caused by inflammation, which then gives rise to pain (Matthiessen and Conaghan, 2017).  While hyaluronic acid and glucosamine are sometimes used to supplement the damage done to the cartilage, NSAIDs are typically prescribed to manage localized inflammation and pain (Rohdewald, 2018).  

However, with pharmaceutical drugs, long-term side effects come into play, which, according to research, can lead to gastrointestinal injuries such as bleeding and perforation in the intestinal tract as well as peptic ulcers (Gooch et. al. 2007).   Additionally, high doses of NSAIDs, according to reports, may lead to kidney failure as well as an increase in one’s blood pressure (Gooch et. al. 2007; Snowden and Nelson, 2011).  As such, pine bark standardized extract in the form of pycnogenol is being researched as a safe alternative, especially over the long term (Snowden and Nelson, 2011).

According to research, pycnogenol behaves like a sustained release of active compounds that can help with pain relief as well as possess anti-inflammatory actions (Rohdewald, 2018) without unwanted side effects.  According to Rohdewald (2018), the sustaining effects of pine bark extract on the body are due to its diverse anti-inflammatory properties and its metabolism in the bloodstream.

A study by Canali et. al. (2009) found that its anti-inflammatory substances, such as catechins, ferulic acid and caffeic acid, were found in blood plasma thirty (30) minutes after consumption, with larger concentrations observed between one (1) and four (4) hours after consumption.  Additionally, ferulic acid was found in the patient’s urine up to 25 hours after ingestion (Canali et. al. 2009).

The positive effects of pycnogenol on arthritis were also observed in three (3) clinical published studies (Belcaro et. al. 2008, Farid et. al. 2007; Cisar et. al. 2008).  These studies were all randomized, double-blinded and had a controlled placebo group.  The participants comprise patients between the ages of Forty-eight (48) and fifty-four (54) years of age, who were suffering from mild Osteoarthritis at either stage 1 or 2.

The patients were administered fifty (50mg) milligrams of pycnogenol to be taken three (3) times daily or a placebo.  The patients were also able to take NSAIDS as needed.  In the first study of Thirty-five (35) volunteers, they reportedly experienced a reduction in pain (-45%) and stiffness, as well as saw improvement in their physical performance due to the improvement in their well-being (Belcaro et al. 2008).  The second study, which was a bit larger, had One Hundred (100) participants. These participants took One Hundred and fifty (150mg/day) milligrams of pycnogenol per day. 

The participants also reportedly experienced a reduction in pain and stiffness as well as an improvement in their physical performance by up to 22% (Cisar et al. 24).  Finally, the third study, which had over One Hundred and Fifty-six (156) participants who also administered One Hundred and Fifty (150 mg/day) milligrams of pycnogenol also experienced a reduction in pain and stiffness, with a significant improvement in physical functions of up to 52%.  These results were not the same for the placebo group, which usually had no effect in all three (3) studies (Farid et. al. 23).

All three (3) studies demonstrated the significant impact pycnogenol can have on the symptoms of Osteoarthritis, even with the reduced intake of NSAIDs. Additionally, the participants did not report any adverse effects with pycnogenol and even reported reduced or mild unwanted effects of the NSAIDs such as headache, dizziness and gastric issues.

You can read more on arthritis, as well as foods that may help with the management of arthritis, in this eBook:

EBook – My Little Fingers (A Book on Arthritis) – Science Simplified + Natural ways to manage it!

Side Effects of Pine Bark Extract

While pine bark extract (commonly marketed as Pycnogenol) is generally considered safe for most individuals when used appropriately, it is not without potential risks.  Some noted side effects include headaches, dizziness, nausea, sleepiness and even skin irritation. These side effects were noted to have been mild in a clinical trial with over seven thousand (7,000) patients (Rohdewald, P. (2015). 

As with any nutritional supplement, its use should be approached with caution—particularly in individuals with pre-existing medical conditions or those taking certain medications.

One of the primary considerations is its potential effect on blood sugar levels. Since pine bark extract may improve glucose metabolism, individuals with conditions such as Diabetes Mellitus should monitor their blood glucose closely, especially if they are already using antidiabetic medications. There is a possibility of additive effects, which could lead to hypoglycemia if not properly managed.

Additionally, due to its antioxidant and mild anti-inflammatory properties, pine bark extract may interact with medications such as:

• blood thinners (anticoagulants)
• antihypertensive drugs
• immunosuppressive therapies

These interactions may either enhance or interfere with the intended effects of these medications. Therefore, individuals on such treatments should consult a healthcare provider before incorporating this supplement into their routine.

Pregnant and breastfeeding women, as well as individuals with autoimmune conditions such as Rheumatoid Arthritis, should exercise additional caution due to limited long-term safety data.

Ultimately, while pine bark extract shows promise, it should not be viewed as a replacement for conventional medical treatment but rather as a potential complementary approach under professional guidance.

Illustrative Summary

Here is a summary of the effects of Pine Bark Extract on Rheumatoid Arthritis and Osteoarthritis.

Let’s Sum Up!

Pine bark extract, or Pycnogenol, represents a compelling example of how plant-based compounds are increasingly being explored for their role in supporting health and managing chronic conditions such as arthritis. Its antioxidant and anti-inflammatory properties provide a strong biological basis for its potential benefits, particularly in reducing oxidative stress and supporting joint function.

However, while early research is promising, it is important to recognize that the current body of evidence is still evolving. Many studies, though encouraging, are limited in scale or duration, and more large-scale clinical trials are needed to establish definitive conclusions regarding its long-term effectiveness and safety.

For individuals seeking natural, evidence-informed approaches to complement their arthritis management plan, pine bark extract may be worth considering. That said, it should be approached as part of a broader, holistic strategy that includes:

• a balanced, nutrient-rich diet
• regular physical activity
• weight management
• and appropriate medical care

As always, informed decision-making is key. Consulting with a qualified healthcare professional can help determine whether this supplement aligns with your individual health needs and goals.

In the end, while pine bark extract is not a cure for arthritis, it may offer supportive benefits for some individuals—making it a potentially valuable addition to a well-rounded wellness approach.

While more research is still warranted to truly confirm the beneficial effects of pine bark on an even broader scale, these studies do provide a ray of hope for millions of people who are battling the condition, mild or severe.  Have you used pine bark extract or pycnogenol before? What did you use it for? How was it? Share it with us nuh!

You can also check out these other posts on foods that can reportedly help with fighting inflammation in the body and, as such, arthritis:

• Cherry O’ Baby – Five (5) Health Benefits of Eating Cherries!
• Magnesium – The quality sleep enhancer plus four (4) more benefits worth knowing!
• Moringa – Nature’s Multivitamin without a Bottle – Here are Five (5) Researched Reasons Why!
• Pycnogenol and Diabetes – Is there a positive link?
• Video: Let’s Talk Pycnogenol and Diabetes

Editor’s Note: This article was last updated by a Researcher and Certified Nutrition Coach on April 14, 2026